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Malaria is caused by the parasitic protozoan Plasmodium. It is a vector-borne disease which is transmitted from person to person via bites from infected Anopheles mosquitoes. Following a mosquito bite the parasites multiply in the liver and subsequently infect red blood cells. remains one of the most serious tropical and subtropical diseases in many countries of the world. bite of infected mosquitoes. Humans are hosts for four main Plasmodium species: P. falciparum, P. vivax, P. ovale, and P. malariae. In humans the parasite called sporozoites migrate to the liver and release another form called merozoites. Globally, ~50% of infections are caused due to P. vivax, ~40% are due to P. falciparum, ~ 10% due to P. malariae and <1% to P. ovale. The disease now occurs in more than 90 countries worldwide, and it is estimated that there are over 500 million clinical cases and 2.7 million malaria-caused deaths per year. At present, malaria is diagnosed by looking for the parasites in a drop of blood. Blood will be put into a microscope slide and stained so that the parasites will be visible under a microscope.